Methlylene Blue

Exploring the Wonders of Methylene Blue: An Insight into Its Exceptional Health Benefits

UNDERSTANDING METHYLENE BLUE: IT’S ORIGIN AND USES

Imagine discovering that a dye once utilized to color denim blue jeans in the 1800s holds the potential to enrich your life with happiness, vitality, and longevity. This might sound improbable initially, but it’s indeed factual!

Methylene Blue has its origins in 1876 (146 years ago) when German chemist Heinrich Caro synthesized the compound as an aniline-based dye for cotton. Originally intended for textile dyeing due to its blueish hue, it became a staple in the fashion industry, playing a significant role in the creation of blue jeans as we know them today.

In 1891, physician Paul Ehrlich discovered its potential as a treatment for malaria, earning Methylene Blue the nickname “Magic Bullet.” Ehrlich found that Methylene Blue possesses a remarkable ability to selectively target diseased tissues in the body.

While it originated as a dye, its versatility has led to widespread applications across various domains:

Treatment of methemoglobinemia: Methylene blue proves effective in managing methemoglobinemia, a rare blood disorder characterized by reduced oxygen-carrying capacity.
Metabolic Poisons: Methylene blue is widely utilized in hospitals worldwide as an antidote for metabolic poisons that impede oxygen transport, such as carbon monoxide or cyanide poisoning. It is listed as an essential antidote by the World Health Organization (WHO).
Addressing neurodegenerative conditions: Recent attention focuses on its potential therapeutic role in conditions like Alzheimer’s and Parkinson’s disease.
Medical procedures: Its characteristic blue hue renders methylene blue invaluable as a contrast agent in staining tissues for microscopic analysis and visualizing the urinary tract in diagnostic assessments.
Dyeing agent: Beyond medicine, it finds use in dyeing fabrics and as a stain in chemical and biological experiments.

The multi-faceted utility of methylene blue extends beyond conventional boundaries, sparking interest in biohacking and performance enhancement due to its profound effects on holistic well-being.

EFFECTS OF METHYLENE BLUE ON THE BODY:

Increased Energy Levels: By enhancing mitochondrial energy production, methylene blue boosts overall energy levels in the body. This not only provides an immediate energy lift but also supports long-term health and vitality.

Effective Nootropic Supplement: Methylene Blue is simply a Nootropic supplement specifically designed to improve brain function, vitality, and mood. In addition to increasing energy consumption and distribution in the brain, this drug enhances mitochondrial functions — the key to unlocking its full beneficial potential. It functions by aiding in brain cell respiration through the enhancement of intracellular oxygen levels, optimizing the transport and exchange of both oxygen (O2) and carbon dioxide (CO2). This process involves the electron transport chain within the mitochondria, which generates the necessary ATP to fuel mitochondrial activities. Consequently, there is a notable increase in oxygen and glucose consumption in the cerebral metabolic rate (CMRO2) via the mitochondrial electron transport.

Memory Enhancement: Research suggests that methylene blue’s promotion of brain oxygen consumption aids in memory retention, offering potential benefits for cognitive function.

Protection Against Neurodegenerative Diseases: Clinical trials indicate that methylene blue inhibits the formation of plaque associated with neurodegenerative diseases like Alzheimer’s. This protective effect positions methylene blue as a potential treatment for such conditions.

Delaying Aging Effects on the Body: As a potent antioxidant, methylene blue helps combat oxidative stress, a major contributor to aging. Studies have shown its efficacy in promoting skin fibroblast proliferation, thus potentially slowing down the aging process.

Mood Improvement: By increasing levels of neurotransmitters like dopamine and serotonin, methylene blue can positively impact mood, alleviating symptoms of depression and anxiety.

Neuroprotection: Animal studies suggest that methylene blue may offer neuroprotection, particularly in conditions like traumatic brain injury, by reducing brain lesions and neural degeneration.

Antifungal, Antiviral and Antibacterial: Researchers and medical professionals have discovered that the synthesized drug has potential beyond treating malaria; it can also serve as an antifungal, antiviral, and antibacterial agent. This versatility was recognized long before regulated pharmaceutical antimicrobials were widely accessible. Interestingly, the same compound known as Methylene Blue, often used as a blue dye in aquariums for fish tanks, is utilized to combat and treat fish fungus.

Overall, methylene blue exhibits versatile therapeutic potential, demonstrating efficacy in various age-related conditions, cognitive disorders, and neurodegenerative diseases.

The Diverse Benefits of Methylene Blue for Human Health

Methylene blue has been associated with a plethora of benefits, including:

Enhanced cognitive function, memory, and focus
Mood enhancement and emotional well-being
Neuroprotection, safeguarding brain cells from damage
Increased energy levels and physical performance
Enhanced physical performance
Anti-aging and Anti-Oxidant properties
Decreased risk of chronic disease development
Reduction in inflammation and signs of aging
Improved heart health and decreased risk of chronic diseases

BUT HOW DOES METHYLENE BLUE ACHIVE SUCH A WIDE-RANGING EFFECTS ON THE HUMAN BODY?

1% Concentrated Solution
1 Gram for 100 Ml of distilled water.

Pills with other Brain & Health Boosting Supplements

Methylene blue influences health through various pathways:

Mitochondrial function and energy production: By facilitating electron transfer within the mitochondria, methylene blue enhances ATP production, thereby optimizing cellular energy and function.
Antioxidant properties and anti-inflammatory action: Acting as an antioxidant, it neutralizes free radicals and mitigates inflammation, protecting cells from oxidative damage and averting chronic diseases.
Regulation of nitric oxide and enhanced oxygen utilization: Methylene blue modulates nitric oxide levels, promoting vasodilation and improving oxygen delivery to cells, thereby enhancing physical endurance and performance.
Neurotransmitter regulation and neuroprotection: Serving as a nootropic, it regulates neurotransmitters, inhibits their breakdown, and stimulates the production of cGMP, enhancing mood, cognition, and protecting neurons from damage.

Moreover, methylene blue exhibits neuroprotective effects by shielding neurons from toxins and stabilizing amyloid proteins, thus impeding neurodegeneration. Methylene blue operates through several distinct mechanisms:

Neurotransmitter Regulation: Neurotransmitters facilitate communication between different brain areas and the body. Methylene blue enhances the release and reuptake of neurotransmitters like serotonin, dopamine, and norepinephrine.
Monoamine Oxidase Inhibition: After release, neurotransmitters are broken down by monoamine oxidase enzymes. Methylene blue inhibits these enzymes, increasing neurotransmitter availability.
Increased cGMP: Cyclic guanosine monophosphate (cGMP) is crucial for various bodily functions, particularly brain function. Methylene blue stimulates cGMP production, elevating levels of this cognition-boosting compound.

These actions contribute to improved mood, focus, learning, and overall cognitive function.

Neuroprotective Effects and Amyloid Protein Binding: Neurodegeneration entails progressive brain and nerve cell damage, often accompanied by the accumulation of amyloid proteins. Methylene blue exhibits neuroprotective properties, shielding neurons from toxins, promoting nerve cell survival, and preventing neurodegenerative conditions. Additionally, it stabilizes amyloid proteins, slowing their aggregation and deposition in the brain.

Despite its remarkable benefits, using methylene blue supplements may entail certain side effects:

Urine Discoloration: Temporary blue or greenish-blue urine discoloration is common after supplementation.

Digestive Upset: Some individuals may experience mild gastrointestinal discomfort, alleviated by taking the supplement with food.

Headache: Headaches or dizziness, though rare, may occur, especially at higher doses.

Interaction with Medications: Methylene blue may interact with certain medications, necessitating consultation with healthcare providers, especially for those on SSRIs or psychiatric drugs.

Allergic Reactions: While uncommon, allergic reactions like rash, itching, or swelling may occur, requiring immediate discontinuation and medical attention.

In general, methylene blue side effects are mild, but individuals with preexisting medical conditions or concerns about drug interactions should consult healthcare professionals before supplementation. Selecting a high-quality methylene blue supplement from reputable manufacturers is crucial.

HOW TO USE METHLYLENE BLUE: DOSAGE

It’s important to note that Methylene Blue is water-soluble, which makes it highly versatile and easy to ingest without the need to consume a meal beforehand.

Option 1: Powder

Purchasing the powder is the most economical option, as you receive 4 grams of pharmaceutical-grade Methylene Blue. However, the subsequent step involves adding 1 gram of Methylene Blue to 100 ml of distilled water. Bionoura offers all three options: as 100% powder, as droppers, and as ready-made nootropic supplements in capsules.

Option 2: Dropper

Starting with a lower dosage involves taking a couple of drops per day and gradually increasing to 4 to 8 drops daily. To create the drops, you can utilize the powder available on this website. Dilute 1 gram of powder in 100ml of distilled water to make the drops. Bionoura offers 4 grams of Methylene Blue at a very affordable price, which allows you to create four 100ml droppers. However, it’s essential to note that Methylene Blue is a dye and can stain surfaces, clothes, and skin. Therefore, ensure that you take the drops in a location where staining can be avoided.

Option 3: Nootropic – Brain Booster

Another option is to purchase Bionoura’s Nootropic Brain Booster capsules, which contain ingredients proven to enhance mental capacity, increase focus, and boost energy levels. Since Methylene Blue is already encapsulated in the capsules, there is no risk of staining, making it more convenient to take. For more information, refer to the Nootropic Brain Booster section under products (navigation tab).

Opting for a lower dosage of Methylene Blue, especially initially, is strongly recommended, as excessive intake may carry potential risks to the body. It’s advisable not to exceed the recommended limits and to avoid surpassing one’s body threshold.

Before commencing the dosage regimen, it’s worth noting a lesser-known fact: the possibility of urine discoloration. Due to its water solubility, Methylene Blue can easily pass through the urinary tract, potentially resulting in urine with a blue tint. Some dedicated users and neuro hackers have suggested taking a vitamin C or ascorbic acid pill three hours prior to Methylene Blue intake to mitigate this occurrence.

WHEN CHOOSING A METHALYNE BLUE SUPPLEMENT, CONSIDER THE FOLLOWING FACTORS:

Pharmaceutical-grade: Ensure the supplement is pharmaceutical-grade for documented purity and potency. Bionoura Methalene Blue is Medical Grade.

Proper Dosing: Select supplements that allow for appropriate dosing based on individual factors.

Clinical Proof: Choose brands with scientific studies supporting their claims and confirming ingredient authenticity. See studies and reference below.

Commitment to Improvement and Education: Opt for transparent brands actively enhancing product quality and providing educational resources for informed decision-making.

High-quality methylene blue supplements meeting these criteria can be found through reputable manufacturers.

IN-CONCLUSION: EMBRACING THE POTENTIAL OF METHYLENE BLUE

Methylene blue, once a humble dye, emerges as a potent ally in the pursuit of holistic well-being. Brands like Troscriptions provide accessible, high-quality supplements harnessing the transformative power of methylene blue.

While methylene blue offers remarkable benefits, it complements, rather than substitutes, a healthy lifestyle. With careful consideration and guidance, integrating methylene blue into your regimen can unlock new dimensions of health, vitality, and resilience.

WARNING & DISCLAIMER

Renal Dose Adjustments
Approximately 40% of this medication is eliminated through renal excretion. Patients with any renal impairment should undergo close monitoring for potential toxicities and drug interactions for an extended duration after therapy.

Liver Dose Adjustments
Methylene blue undergoes extensive hepatic metabolism. Patients with any hepatic impairment should be monitored for potential toxicities and drug interactions for an extended duration following therapy.

Precautions
There is a risk of serotonergic syndrome when this medication is used concurrently with serotonergic drugs. Avoid combining this medication with selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors.

Medical Disclaimer: Before initiating the use of this medication, it is essential to consult a qualified healthcare professional, such as a doctor or pharmacist. Individuals should seek medical advice if they experience any adverse reactions or unexpected symptoms while using this medication. It is advisable to start with small doses initially to assess how the body responds and interacts with the medication.

* Any of the statements in this website and webpage have not been evaluated by the Food and Drug Administration. The product mentioned in this article are not intended to diagnose, treat, cure, or prevent any disease. The information in this article is not intended to replace any recommendations or relationship with your physician. Please review references sited at end of article for scientific support of any claims made.

RESOURCES AND STUDIES

Potential Health Benefits of Methylene Blue (news-medical.net)

The Potentials of Methylene Blue as an Anti-Aging Drug – PMC (nih.gov)

Methylene-Blue-Cognitive-Vitality-For-Researchers.pdf (alzdiscovery.org)

Therapeutic benefits of methylene blue on cognitive impairment during chronic cerebral hypoperfusion – PubMed (nih.gov)

Protection against neurodegeneration with low-dose methylene blue and near-infrared light – PMC (nih.gov)

Methylene Blue in the Treatment of Neuropsychiatric Disorders – PubMed (nih.gov)

Methylene Blue: Revisited – PMC (nih.gov)

Cellular and Molecular Actions of Methylene Blue in the Nervous System – PMC (nih.gov)

Methylene Blue – StatPearls – NCBI Bookshelf (nih.gov)

MORE RESEARCH AND STUDIES

Wainwright M, Crossley KB. Methylene blue—a therapeutic dye for all seasons? J Chemother 2002;14:431–43.

Frankenburg FR, Baldessarini RJ. Neurosyphilis, malaria, and the discovery of antipsychotic agents. Harv Rev Psychiatry 2008;16:299–307.

Wainwright M. The use of dyes in modern biomedicine. Biotech Histochem 2003;78:147–55.

Bodoni P. Dell’azione sedativa del bleu di metilene in varie forme di psicosi. Clin Med Ital 1989;24:217–22.

Rojas, J. C., Bruchey, A. K., & Gonzalez-Lima, F. (2012). Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue. Progress in Neurobiology, 96(1), 32–45.doi:10.1016/j.pneurobio.2011.10.007

Duicu, O. M., Privistirescu, A., Wolf, A., Petrus, A., Danila, M. D., Ratiu, C. D., … Sturza, A. (2017). Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts. Canadian Journal of Physiology and Pharmacology, 95(11), 1376–1382. doi:10.1139/cjpp-2017-0074

Talley Watts, L., Long, J. A., Chemello, J., Van Koughnet, S., Fernandez, A., Huang, S., … Duong, T. Q. (2014). Methylene Blue Is Neuroprotective against Mild Traumatic Brain Injury. Journal of Neurotrauma, 31(11), 1063–1071.doi:10.1089/neu.2013.3193

Ramsay, R. R., Dunford, C., & Gillman, P. K. (2007). Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. British Journal of Pharmacology, 152(6), 946–951. doi:10.1038/sj.bjp.0707430

Gureev, A. P., Syromyatnikov, M. Y., Gorbacheva, T. M., Starkov, A. A., & Popov, V. N. (2016). Methylene blue improves sensorimotor phenotype and decreases anxiety in parallel with activating brain mitochondria biogenesis in mid-age mice. Neuroscience Research, 113, 19–27.doi:10.1016/j.neures.2016.07.006

Riha, P. D., Bruchey, A. K., Echevarria, D. J., & Gonzalez-Lima, F. (2005). Memory facilitation by methylene blue: Dose-dependent effect on behavior and brain oxygen consumption. European Journal of Pharmacology, 511(2-3), 151–158.doi:10.1016/j.ejphar.2005.02.001

Callaway, N. L., Riha, P. D., Bruchey, A. K., Munshi, Z., & Gonzalez-Lima, F. (2004). Methylene blue improves brain oxidative metabolism and memory retention in rats. Pharmacology Biochemistry and Behavior, 77(1), 175–181.doi:10.1016/j.pbb.2003.10.007

Medina, D. X., Caccamo, A., & Oddo, S. (2011). Methylene Blue Reduces Aß Levels and Rescues Early Cognitive Deficit by Increasing Proteasome Activity. Brain Pathology, 21(2), 140–149.doi:10.1111/j.1750-3639.2010.00430.x

Atamna, H., & Kumar, R. (2010). Protective Role of Methylene Blue in Alzheimer’s Disease via Mitochondria and Cytochrome c Oxidase. Journal of Alzheimer’s Disease, 20(s2), S439–S452.doi:10.3233/jad-2010-100414

Oz, M., Lorke, D. E., & Petroianu, G. A. (2009). Methylene blue and Alzheimer’s disease. Biochemical Pharmacology, 78(8), 927–932.doi:10.1016/j.bcp.2009.04.034

Xiong, Z.-M., O’Donovan, M., Sun, L., Choi, J. Y., Ren, M., & Cao, K. (2017). Anti-Aging Potentials of Methylene Blue for Human Skin Longevity. Scientific Reports, 7(1).doi:10.1038/s41598-017-02419-3

Xiong, Z.-M., Choi, J. Y., Wang, K., Zhang, H., Tariq, Z., Wu, D., … Cao, K. (2015). Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell, 15(2), 279–290.doi:10.1111/acel.12434

Vaccaro, A., Patten, S. A., Ciura, S., Maios, C., Therrien, M., Drapeau, P., … Parker, J. A. (2012). Methylene Blue Protects against TDP-43 and FUS Neuronal Toxicity in C. elegans and D. rerio. PLoS ONE, 7(7), e42117.doi:10.1371/journal.pone.0042117

Alda, M., McKinnon, M., Blagdon, R., Garnham, J., MacLellan, S., O’Donovan, C., … MacQueen, G. (2017). Methylene blue treatment for residual symptoms of bipolar disorder: Randomised crossover study. British Journal of Psychiatry, 210(01), 54–60. doi:10.1192/bjp.bp.115.173930

Naylor, G. J., Martin, B., Hopwood, S. E., & Watson, Y. (1986). A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manicdepressive psychosis. Biological Psychiatry, 21(10), 915–920.doi:10.1016/0006-3223(86)90265-9

Narsapur, S. L., & Naylor, G. J. (1983). Methylene blue. Journal of Affective Disorders, 5(2), 155–161.doi:10.1016/0165-0327(83)90008-3

Yang, S.-H., Li, W., Sumien, N., Forster, M., Simpkins, J. W., & Liu, R. (2017). Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots. Progress in Neurobiology, 157, 273–291. doi:10.1016/j.pneurobio.2015.10.005

Tucker, D., Lu, Y., & Zhang, Q. (2017). From Mitochondrial Function to Neuroprotection—an Emerging Role for Methylene Blue. Molecular Neurobiology, 55(6), 5137–5153.doi:10.1007/s12035-017-0712-2

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